Shannon Brown Fedenko

Vice President, Research

Shannon Brown Fedenko received her BS in Biological Engineering with minors in Nutrition and Biomechanics, and her PhD in Biomedical Engineering from the University of Florida. Dr. Fedenko’s background is in drug delivery and regenerative medicine, particularly as it applies to musculoskeletal injuries and diseases. She has established multiple models for cell and tissue culture, with emphasis on cartilage and synovium research. Dr. Fedenko’s research is strongly focused on cartilage and joint pathology, and she is driven to advance regenerative medicine options for patients suffering from orthopaedic trauma and disease. Dr. Fedenko was awarded graduate fellowships from the National Science Foundation, Institute for Cell and Tissue Science and Engineering, and the University of Florida Graduate School. Dr. Fedenko has been recognized for excellence through the Committee of 200, the American Society of Agricultural and Biological Engineers, Tau Beta Pi nationals, and the University of Florida.

Selected Publications

  • S. Brown, L. Wang, R. Jungels, B. Sharma. Effects of cartilage-targeting moieties on nanoparticle biodistribution in healthy and osteoarthritic joints. Acta Biomaterialia. E-Pub 2019; Oct 4. 2020 Jan 1.

  • S. Brown, J. Hornyak, R. Jungels, Y. Y. Shah, E. G. Yarmola, K. D. Allen, B. Sharma, Characterization of post-traumatic osteoarthritis in rats following ACL rupture by non-invasive knee injury (NIKI). J Orthop Res. 2019 Sep 14.

  • S. Kumar, I. Adjei, S. Brown, O. Liseth, B. Sharma. Manganese Dioxide Nanoparticles Protect Cartilage from Inflammation-Induced Oxidative Stress. Biomaterials. 2019; 224. Featured as the Editor’s Choice for Science Translational Medicine.

  • S. Brown, S. Kumar, and B. Sharma. Intra-articular targeting of nanomaterials for the treatment of osteoarthritis. Acta Biomaterialia. 2019 Jul 15; 93:239-257.

  • I. Adjei, M. Temples, S. Brown, and B. Sharma. Targeted nanomedicine to treat bone metastasis. Pharmaceutics. 2018 Oct 25; 10(4):205.

  • S. Brown, J. Pistiner, I. Adjei, and B. Sharma. Nanoparticle properties for delivery to cartilage: the implications of disease state, synovial fluid, and off-target uptake. Mol Pharmaceutics. 2019; 16 (2):469–479. Published online July 2017.